Practice Sets
NPC Daily Practice Sets (5 Sets)
Choose your set below to practice 30 high-yield questions with instant feedback.
Set 01
30 MCQs
General Pharmacology & ANS
Receptors, pharmacokinetics, cholinergic & adrenergic drugs, and bioavailability.
Start Set 01
Set 02
30 MCQs
Clinical & Hospital Pharmacy
Adverse drug reactions, drug interactions, prescription audit, and hospital formulary.
Start Set 02
Set 03
30 MCQs
Pharmaceutics & Dosage Forms
Formulation design, tablets, capsules, sterile parenterals, and GMP standards.
Start Set 03
Set 04
30 MCQs
Pharmacognosy & Phytochemistry
Medicinal plants of Nepal, alkaloids, glycosides, and herbal standardization.
Start Set 04
Set 05
30 MCQs
Jurisprudence & Drug Act 2035
Pharmacy Council Act 2057, Narcotic Control Act, DDA guidelines, and ethics.
Start Set 05
Full Length
NPC Weekly Grand Mock Tests
Full-length 100 questions simulating the official Nepal Pharmacy Council licensing exam.
NPC Daily Practice Set #01
Click any option: Correct turns Green, Wrong turns Red with immediate correct answer display
30 High-Yield MCQs
Exit Set
1. Which route of drug administration provides 100% bioavailability?
Correct Answer: C) Intravenous (IV) — Intravenous injection places the drug directly into the systemic circulation, defining 100% bioavailability.
2. Which antidote is specifically indicated for paracetamol (acetaminophen) toxicity?
Correct Answer: B) N-acetylcysteine — Restores liver glutathione stores to detoxify reactive toxic metabolite NAPQI.
3. Which antibiotic causes 'Grey Baby Syndrome' due to deficient glucuronidation?
Correct Answer: A) Chloramphenicol — Neonates lack sufficient UDP-glucuronyltransferase enzyme, leading to toxic accumulation.
4. Atropine belongs to which pharmacological class?
Correct Answer: B) Antimuscarinic agent — Competitive antagonist at muscarinic acetylcholine receptors.
5. The primary organ responsible for drug biotransformation in humans is:
Correct Answer: B) Liver — Principal site containing Cytochrome P450 enzymes for phase I & II metabolism.
6. What is the mechanism of action of Aspirin?
Correct Answer: A) Irreversible inhibition of COX enzymes — Covalently acetylates COX-1 and COX-2.
7. Which of the following is a Loop Diuretic?
Correct Answer: B) Furosemide — Inhibits the Na+/K+/2Cl- cotransporter in the thick ascending limb of the loop of Henle.
8. What is the specific opioid receptor antagonist used in morphine overdose?
Correct Answer: A) Naloxone — Pure competitive antagonist at opioid receptors.
9. Which drug is an Angiotensin Converting Enzyme (ACE) inhibitor?
Correct Answer: B) Enalapril — ACE inhibitor converting to enalaprilat in vivo.
10. Sublingual nitroglycerin is administered in angina primarily to:
Correct Answer: A) Avoid first-pass hepatic metabolism — Bypasses liver straight into vena cava for rapid relief.
11. Which adverse effect is characteristic of ACE inhibitors due to bradykinin accumulation?
Correct Answer: A) Dry persistent cough — ACE inhibition stops breakdown of pulmonary bradykinin.
12. Omeprazole exerts its pharmacological action by inhibiting:
Correct Answer: B) Gastric H+/K+ ATPase pump — Irreversibly blocks the final step of acid secretion.
13. Metformin belongs to which class of oral antidiabetic agents?
Correct Answer: B) Biguanide — Reduces hepatic gluconeogenesis and improves peripheral insulin uptake.
14. Which antibiotic causes teeth discoloration and enamel hypoplasia in children?
Correct Answer: B) Tetracycline — Chelates calcium orthophosphate in developing teeth and bones.
15. What is the drug of first choice for acute anaphylactic shock?
Correct Answer: B) Intramuscular Adrenaline (Epinephrine) — Rapidly restores vascular tone and dilates bronchioles.
16. Simvastatin produces lipid-lowering action through inhibition of:
Correct Answer: A) HMG-CoA reductase — Limits de novo cholesterol biosynthesis in the liver.
17. Unfractionated Heparin activity is routinely monitored using which test?
Correct Answer: B) Activated Partial Thromboplastin Time (aPTT) — Monitors the intrinsic coagulation pathway.
18. Warfarin exerts anticoagulant activity by antagonizing which vitamin?
Correct Answer: B) Vitamin K — Blocks epoxide reductase, halting factors II, VII, IX, and X synthesis.
19. Which anti-tubercular drug causes harmless red-orange discoloration of urine?
Correct Answer: B) Rifampicin — Its metabolite is a red-orange pigment excreted in body secretions.
20. What is the classic drug of choice for acute termination of status epilepticus?
Correct Answer: A) Intravenous Lorazepam / Diazepam — Immediate potentiation of GABAergic neurotransmission.
21. Ciprofloxacin is classified under which class of antimicrobial agents?
Correct Answer: A) Fluoroquinolones — Inhibits bacterial DNA gyrase and topoisomerase IV.
22. Digoxin toxicity is aggravated by which concurrent electrolyte disorder?
Correct Answer: A) Hypokalemia — Facilitates digoxin binding to myocardial Na+/K+ ATPase pump.
23. Under Nepal Drug Act 2035, the chief regulatory body responsible for drug registration is:
Correct Answer: A) Department of Drug Administration (DDA) — Primary authority registering pharmaceuticals and enforcing Drug Act 2035.
24. What is the standard temperature specification for "Cold storage" in pharmacy?
Correct Answer: A) 2°C to 8°C — Standard pharmacopoeial definition for refrigerated biologicals and vaccines.
25. Which excipient is commonly used as a superdisintegrant in solid dosage formulation?
Correct Answer: A) Crosscarmellose sodium — Swells rapidly to break tablets into granules quickly.
26. Which alkaloid obtained from Cinchona bark is used as an antimalarial drug?
Correct Answer: A) Quinine — Quinoline alkaloid isolated from Cinchona bark.
27. Yarsagumba (Cordyceps sinensis), a celebrated medicinal species found in Himalayan Nepal, is a:
Correct Answer: A) Entomopathogenic fungus on ghost moth caterpillar — Complex of Cordyceps fungus and ghost moth larva.
28. Which schedule under Nepal Pharmacy Council Act governs registration categories?
Correct Answer: A) Pharmacist in Group A and Assistant Pharmacist in Group B — Defined categories under NPC regulations.
29. Moist heat sterilization using pressurized saturated steam is carried out in:
Correct Answer: A) Autoclave (121°C for 15-20 min) — Saturated steam under 15 psi pressure kills spores and bacteria.
30. Limulus Amebocyte Lysate (LAL) test is standardly utilized in pharmacy quality control for:
Correct Answer: A) Bacterial Endotoxins / Pyrogen detection — Gels specifically in response to Gram-negative bacterial lipopolysaccharides.
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